Are polynucleotide injections truly effective in skin rejuvenation?


Nowadays, those seeking to alleviate the signs of aging and rejuvenate their skin appearance are increasingly seeking treatment in aesthetic clinics. So, how effective are polynucleotide injections, which we've been hearing about frequently in recent years, in this regard? Does this treatment method, which has ushered in a new era in skin health and aesthetic medicine, really work?

In this blog post, we discuss the use, effectiveness, and safety of polynucleotides (PN) in aesthetic medicine, based on information based on scientific literature.

What are polynucleotides, and why have they become so popular?
Polynucleotides are biological molecules containing DNA-based structures, obtained from the gonads of fish such as salmon and trout. Initially used in medicine for wound healing and tissue regeneration, they have since been recognized as having significant potential for skin rejuvenation and aesthetic applications.

Thanks to their natural structure, compatibility with the body, and cell-stimulating properties, they stand out as a minimally invasive, rapid-healing, and low-risk option.

What do scientific studies say about polynucleotides?
A systematic review of scientific studies conducted between January 1, 2010, and January 1, 2024, shows that PN injections are effective in reducing wrinkles, improving skin texture, and increasing elasticity.

The nine studies included in this systematic review included a total of 219 patients, and differences were observed between injection sites and application techniques. However, the results demonstrated statistically significant skin improvements in most studies.

What are the side effects and patient satisfaction levels?
Post-treatment side effects are generally mild and transient. For example, mild redness, edema, or tenderness at the injection site are rare and resolve on their own within a short time.

Patient satisfaction ranges from moderate to high, demonstrating that PN injections are both tolerable and effective.

In which areas are they used?
Facial rejuvenation

Wrinkles around the eyes

Neck and décolleté rejuvenation

Polynucleotide injections are frequently preferred in areas such as hair restoration.

It is also used as a supplementary method in some treatments.

What do scientists recommend?
Although the data demonstrating the effectiveness of PNs in aesthetic medicine is promising, there is still no clear clinical consensus on this treatment method. Experts state that larger sample sizes, longer-term randomized controlled trials are needed.

However, the available data demonstrate that polynucleotide injections are both safe and effective skin rejuvenation methods.

Conclusion: Are polynucleotide injections gaining ground in aesthetic medicine?

Yes, polynucleotides offer an attractive option, especially for patients seeking natural and minimally invasive treatments. With benefits such as wrinkle reduction, increased skin elasticity, and overall rejuvenation, they could herald a new era in aesthetic medicine.

However, it's important to remember that factors such as the experience of the physician performing the procedure, the correct product selection, and the injection technique play a significant role in success. Therefore, it's important for patients considering PN injections to seek expert and reliable treatment options.

Dermatologist Dr. Fatma Yıldız
Ankara Life Polyclinic