Could polynucleotides replace traditional methods in skin rejuvenation?


As demand for skin rejuvenation in aesthetic medicine increases, patients are now turning to treatments that offer natural, long-lasting, and safe results rather than merely temporary and superficial solutions. In this regard, a frequently heard-about procedure stands out: polynucleotide (PN) injections.

So, are these molecules truly effective enough to surpass other traditional methods? Can they improve skin appearance while also contributing to its health?

Why are polynucleotides attracting so much attention?
Polynucleotides are biological molecules that stimulate cell regeneration and tissue repair. Originally used for wound healing, these substances are now used in aesthetic medicine to increase skin elasticity, reduce wrinkles, regulate pigment balance, and improve overall skin health.

In recent years, interest in natural and subtle approaches in the aesthetic world has increased, and PN injections have emerged as a non-surgical, non-invasive, and short-term alternative.

What does the scientific data say? According to systematic reviews, PN injections:

Not only provide hydration and radiance to the skin, but also have a regenerative effect on deep tissues.

They reduce wrinkle depth, even out skin tone, and increase elasticity.

They also have positive effects on parameters directly related to skin health, such as melanin and hemoglobin balance.

Most importantly, aside from mild and temporary side effects, no serious complications are observed.

These effects make PNs not just a cosmetic solution but also a treatment that supports skin health.

What are their advantages compared to other methods?
While hyaluronic acid fillers or collagen-stimulating agents can occasionally cause complications such as deformities, edema, and granulomas,

PN injections can be performed without any serious adverse events.

Compared to blood-derived treatments such as PRP or PRF, they require less preparation time for the clinician and offer a cost advantage.

In these respects, polynucleotides make a difference, particularly in terms of safety and ease of application.

Are there any limitations?

Yes, while existing studies are promising, many have been conducted with small sample sizes, different protocols, and short follow-up periods. This limits the generalizability of the data obtained.

Furthermore, many studies lack 3D analysis, objective measurement devices, and long-term follow-up. Future clinical trials with larger, standardized protocols will fill these gaps.

Will PN injections find a place in dermatological practice?

According to current findings, the answer is: Yes. PN injections are rapidly gaining ground among dermatological aesthetic procedures thanks to their multi-layered and long-term effects, not just superficial effects on the skin, their low risk of complications, and their natural ingredients.

Although further research is needed, PNs have become an important alternative for patients who prefer natural and biological approaches that align with today's aesthetic expectations.

In conclusion, are polynucleotides not a transition, but a transformation?
Polynucleotide injections: For individuals seeking fast, safe, and effective results, this may not just be a temporary trend, but a sign of a permanent transformation in aesthetic medicine. This treatment, which not only rejuvenates the skin but also improves its structure, is poised to become a staple in dermatology clinics in the future.

However, as with any procedure, polynucleotide injections require a personalized evaluation by a specialist dermatologist, and a treatment plan should be developed accordingly.

Dermatologist Fatma Yıldız
Ankara Life Polyclinic