What are the new developments in polynucleotide skin rejuvenation?


Rapid advances in medical aesthetics in recent years have significantly increased interest in skin rejuvenation treatments. The goal is no longer just to eliminate wrinkles; it's also to improve skin health, restore elasticity, revitalize texture, and restore a natural glow. Numerous methods are used for this purpose, from laser treatments to botulinum toxin, chemical peels to microneedling. However, a new approach that has recently gained significant traction is polynucleotide (PN)-based biorevitalization.

So, what are polynucleotides? How do they contribute to skin rejuvenation? And most importantly, is this treatment truly effective and safe? Here are some interesting facts about PN treatments, based on scientific data...

What are polynucleotides and how are they obtained?
Polynucleotides (PN) and polydeoxyribonucleotides (PDRN) are purified DNA fragments obtained from the gonads of fish such as salmon and trout. These molecules support important biological functions such as promoting skin cell regeneration, increasing collagen production, and promoting tissue repair. Their natural origin makes them more attractive and well-tolerated than synthetic agents.

How does the use of PN in skin rejuvenation work?
A recent systematic review examined nine different studies on PN-based skin rejuvenation treatments. Most of these studies were conducted in Korea, while two were conducted in Italy, and evaluated 219 patients. The findings are quite promising:

Wrinkle reduction: Six studies found that PN injections improved the appearance of wrinkles. A significant reduction in crow's feet was reported, in particular. In the studies that achieved statistically significant results, the effects lasted for up to 6 months.

Skin texture and elasticity: Significant improvements in skin texture and elasticity were observed after PN application. Pore volume decreased, skin thickness increased, and hydration increased. Some studies reported these effects as early as 2 weeks and lasted up to 12 weeks.

Skin tone, melanin, and hemoglobin: PN treatments also helped even out skin tone, reduce post-inflammatory pigmentation, and control melanin levels.

How safe is the treatment?
No serious side effects were reported in any of the reviewed studies. The most common side effects included local reactions such as mild pain, itching, edema, or temporary redness at the application site. These effects usually resolved spontaneously within one week.

Compared to HA (hyaluronic acid) fillers or collagen-stimulating agents, PNs have a much lower risk of causing more serious side effects, such as skin irregularities, granuloma formation, and edema. This makes them a safer option.

What is the level of patient satisfaction?
Studies have found very high patient satisfaction levels after PN treatments. In some studies, all patients stated that they were willing to undergo the treatment again. High satisfaction scores were also recorded on self-assessment scales such as the GAIS.

What are the advantages compared to other methods?
Polynucleotides can provide similar results to regenerative treatments such as PRP (platelet-rich plasma) or PRF (platelet-rich fibrin). However, they are easier to prepare, more time-efficient, and less dependent on clinician skill. They may also be more cost-effective.

HA fillers, while more invasive, may be superior in terms of durability. However, PNs offer a much more holistic effect for those looking to add not only volume to the skin but also an overall healthy appearance.

Could polynucleotides be the future star in aesthetics?

While the results are quite promising, the available data is still limited. The study methodologies differ, and sample sizes are generally small. Therefore, more high-quality, randomized controlled trials are needed for PNs to become a standard treatment protocol for skin rejuvenation.

Nevertheless, current findings suggest that PN-based treatments are an important alternative for patients seeking more natural, safer, and lower-risk aesthetic solutions.

Conclusion: Is the PN era in skin rejuvenation beginning? In the world of skin rejuvenation, polynucleotides stand out as a powerful option, boasting both efficacy and safety. For individuals seeking to restore skin moisture balance, increase elasticity, reduce wrinkles, and improve overall appearance, PN treatments are poised to gain a solid place among next-generation aesthetic solutions. If you're looking for a more natural and scientifically based approach to skincare, it's best to consider polynucleotides after consulting a specialist.